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dc.contributor.authorSunman, Birce
dc.contributor.authorYurdakök, Kadriye
dc.contributor.authorKocer-Gumusel, Belma
dc.contributor.authorÖzyüncü, Özgür
dc.contributor.authorAkbıyık, Filiz
dc.contributor.authorBalcı, Aylin
dc.contributor.authorÖzkemahlı, Gizem
dc.contributor.authorErkekoğlu, Pınar
dc.contributor.authorYurdakök, Murat
dc.date.accessioned2021-01-25T07:21:22Z
dc.date.available2021-01-25T07:21:22Z
dc.date.issued2019-06-03
dc.identifier.other31170452
dc.identifier.urihttp://hdl.handle.net/20.500.12591/499
dc.description.abstractBisphenol A (BPA) and phthalates can adversely affect the fetal development. However, observational studies on the effects of these chemicals on fetal male reproductive system are still limited. A hundred of umbilical cord blood samples were analyzed for the levels of BPA, di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and sex hormones. After birth, male newborns underwent physical examination that included measurements of anogenital distance, stretched penile length (SPL), and penile width. BPA, DEHP and MEHP levels were detectable in ≈99% of cord blood samples. In covariate-adjusted models, cord blood BPA levels were inversely associated with SPL of newborns and positively associated with cord blood estradiol levels. In addition, there was a significant inverse relationship between cord blood DEHP levels and anogenital distance index of newborn males. Our results suggest that in utero BPA and DEHP exposure exerted adverse effects on fetal male reproductive development and cord blood estradiol levels.en_US
dc.language.isoengen_US
dc.publisherEzcacılık Fakültesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAnogenital distanceen_US
dc.subjectBisphenol Aen_US
dc.subjectPenile measurementsen_US
dc.subjectPhthalatesen_US
dc.subjectPrenatal exposureen_US
dc.subjectSex hormone levelsen_US
dc.titlePrenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels.en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.contributor.departmentFarmasötik Teknolojien_US


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