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dc.contributor.authorBayraktar, Atilla
dc.contributor.authorErbas, Deniz
dc.contributor.authorAkarca Dizakar, Saadet Ozen
dc.contributor.authorGoktas, Tayfun
dc.contributor.authorOmeroglu, Suna
dc.contributor.authorOz Oyar, Eser
dc.date.accessioned2020-12-25T06:40:01Z
dc.date.available2020-12-25T06:40:01Z
dc.date.issued2020-10-01
dc.identifier.other30894036
dc.identifier.urihttp://hdl.handle.net/20.500.12591/420
dc.description.abstractHepcidin is the main hormone in the regulation of iron metabolism which is also released from the heart. The aim of our study was to investigate the effects of hepcidin on the cardiac ischemia-reperfusion injury. In this study, 12 Wistar albino rats were divided into two groups ( 6 each): 1) The ischemia-reperfusion group (Group 1); 2) Hepcidin-treated group (Group 2). Rat hearts were perfused on Langendorff system with KH (Krebs-Henseleit) and subjected to 30 min stabilization, 30 min global ischemia, and 30 min reperfusion. Hepcidin ( M) was applied to group 2 at the onset of ischemia. Malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NOx) levels were measured in heart tissue for NOx levels, viscosity, and ion content of perfusate were collected before ischemia and the 1st, 5th, 10th, 20th, and 30th minutes of reperfusion were determined. Apoptosis in heart was evaluated. NOx and MDA levels significantly decreased in heart tissue in Hepcidin-treated group. NOx and viscosity of perfusate were not significantly different between the groups. Perfusate iron, calcium, magnesium, potassium, and sodium levels in group 2 were more homogeneous. Histologic structures of heart tissue were regularly in group 2. Apoptosis were increased in control group compared to hepcidin treated group. These results suggest that hepcidin may have a protective effect on the heart for the ischemia-reperfusion injury.en_US
dc.language.isoengen_US
dc.publisherSağlık Bilimleri Enstitüsüen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectapoptosisen_US
dc.subjectcaspase-9en_US
dc.subjecthearten_US
dc.subjecthepcidinen_US
dc.subjectischemiaen_US
dc.subjectreperfusionen_US
dc.titleThe Effect of Hepcidin on Cardiac Ischemia-Reperfusion Injury.en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.contributor.departmentTemel Tıp Bilimlerien_US


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