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dc.contributor.authorTan, Turkan Seda
dc.contributor.authorTuran Serifler, Nazli
dc.contributor.authorDemirtola, Ayse Irem
dc.contributor.authorAkbulut, Irem Muge
dc.contributor.authorOzyuncu, Nil
dc.contributor.authorVurgun, Veysel Kutay
dc.contributor.authorEsenboga, Kerim
dc.contributor.authorKurklu, Haci Ali
dc.contributor.authorKozluca, Volkan
dc.contributor.authorGerede Uludag, Demet Menekse
dc.contributor.authorOngun, Aydan
dc.contributor.authorDincer, Irem
dc.description.abstractPurpose: An elevated left ventricular (LV) filling pressure is the main finding in heart failure patients with preserved ejection fraction, which is estimated with an algorithm using echocardiographic parameters recommended by the recent American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) guidelines. In this study, we sought to determine the efficacy of the LV global longitudinal strain (GLS) in predicting an elevated LV filling pressure. Methods and results: A total of 73 prospectively selected patients undergoing LV catheterization (mean age 63.19 ± 9.64, 69% male) participated in this study. Using the algorithm, the LV filling pressure was estimated using the echocardiographic parameters obtained within 24 hours before catheterization. The LV GLS was measured using an automated functional imaging system (GE, Vivid E9 USA). Invasive LV pre-A pressure corresponding to the mean left atrial pressure (LAP) was used as a reference, and a LAP of >12 mm Hg was defined as elevated. Invasive LV filling pressure was elevated in 43 patients (59%) and normal in 30 patients (41%). Nine of 73 (12%) patients were defined as indeterminate based on the 2016 algorithm. Using the ROC method, -18.1% of LV GLS determined the elevated LAP (AUC =0.79; specificity, 73%; sensitivity, 84%) with better sensitivity compared to that by the algorithm (AUC =0.76; specificity, 77%; sensitivity, 72%). Conclusions: We demonstrated that LV GLS was an independent predictor of elevated LAP as the E/e' ratio and TR jet velocity and may be used as a major criterion for the diagnosis of HFpEF.en_US
dc.publisherTıp Fakültesien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectdiastolic dysfunctionen_US
dc.subjectheart failureen_US
dc.subjectleft ventricular ejection fractionen_US
dc.subjectleft ventricular filling pressureen_US
dc.subjectmyocardial strainen_US
dc.titleInvasive validation of the left ventricular global longitudinal strain for estimating left ventricular filling pressure.en_US
dc.contributor.departmentDahili Tıp Bilimlerien_US

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