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dc.contributor.authorBou-Teen, Diana
dc.contributor.authorKaludercic, Nina
dc.contributor.authorWeissman, David
dc.contributor.authorTuran, Belma
dc.contributor.authorMaack, Christoph
dc.contributor.authorDi Lisa, Fabio
dc.contributor.authorRuiz-Meana, Marisol
dc.date.accessioned2021-04-20T11:33:12Z
dc.date.available2021-04-20T11:33:12Z
dc.date.issued2021-03-11
dc.identifier.other33716106
dc.identifier.urihttp://hdl.handle.net/20.500.12591/549
dc.description.abstractExcessive mitochondrial ROS production has been causally linked to the pathophysiology of aging in the heart and other organs, and plays a deleterious role in several age-related cardiac pathologies, including myocardial ischemia-reperfusion injury and heart failure, the two worldwide leading causes of death and disability in the elderly. However, ROS generation is also a fundamental mitochondrial function that orchestrates several signaling pathways, some of them exerting cardioprotective effects. In cardiac myocytes, mitochondria are particularly abundant and are specialized in subcellular populations, in part determined by their relationships with other organelles and their cyclic calcium handling activity necessary for adequate myocardial contraction/relaxation and redox balance. Depending on their subcellular location, mitochondria can themselves be differentially targeted by ROS and display distinct age-dependent functional decline. Thus, precise mitochondria-targeted therapies aimed at counteracting unregulated ROS production are expected to have therapeutic benefits in certain aging-related heart conditions. However, for an adequate design of such therapies, it is necessary to unravel the complex and dynamic interactions between mitochondria and other cellular processes.en_US
dc.publisherTıp Fakültesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAGEsen_US
dc.subjectAgingen_US
dc.subjectCardiomyocytesen_US
dc.subjectCardioprotectionen_US
dc.subjectSarcoplasmic reticulumen_US
dc.titleMitochondrial ROS and mitochondria-targeted antioxidants in the aged heart.en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.contributor.departmentTemel Tıp Bilimlerien_US


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