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dc.contributor.authorKaplan, Aydin
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorUgur, Mustafa
dc.contributor.authorAydogan, Akin
dc.contributor.authorOzgur, Tumay
dc.contributor.authorCalıskan, Yasemin
dc.contributor.authorYetim, Ibrahim
dc.contributor.authorPaltaci, Ilhan
dc.contributor.authorTemiz, Muhyittin
dc.date.accessioned2020-12-31T06:36:01Z
dc.date.available2020-12-31T06:36:01Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/20.500.12591/434
dc.description.abstractIntroduction: Tissue perfusion plays an important role in pancreatitis. Free oxygen radicals also have some triggering roles in the severity of acute pancreatitis. Tirofiban hydrochloride (TH) is being used for ischemic disorders for many years and is known as an antiaggregant drug. We aimed to determine the therapeutic effects of tirofiban in cerulein-induced acute pancreatitis in this animal study. Materials and methods: Twenty-four Wistar-Albino male rats were divided into three equal groups; Group I: Sham-operated group, Group II: cerulein induced pancreatitis group, Group III: cerulein induced pancreatitis + treatment group (intraperitoneal 0.25 mg tirofiban hydrochloride in 1 ml isotonic saline solution). Amylase and lipase levels were studied in blood samples and malondialdehyde, glutathione peroxidase and superoxide dismutase activities were measured in tissue samples. Results: Amylase and lipase levels were elevated in acute pancreatitis group. The levels of both enzymes were decreased after the rats were medicated with TH. Malondialdehyde (MDA) was higher in pancreatitis group without treatment. There were no significant differences between groups according to glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels. Conclusion: The present findings suggest that TH has an antiaggregant effect and may reduce the progression and improve the healing of acute pancreatitis.en_US
dc.publisherTıp Fakültesien_US
dc.relation.ispartofseries31;1253
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAcute pancreatitis, reactive oxygen species, Tirofiban hydrochloride, Glycoprotein IIb-IIIa inhibitoren_US
dc.titleSAFETY AND EFFICACY OF TIROFIBAN HYDROCHLORIDE (TH) IN CERULEIN-INDUCED ACUTE PANCREATITISen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.contributor.departmentTemel Tıp Bilimlerien_US


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