• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • TIP FAKÜLTESİ
  • Makale
  • Web of Science İndeksli Yayınlar
  • View Item
  •   DSpace Home
  • TIP FAKÜLTESİ
  • Makale
  • Web of Science İndeksli Yayınlar
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Transcriptional splice variants of CD40 and its prognostic value in breast cancer

Thumbnail
View/Open
Transcriptional splice variants of CD40 and its prognostic value in breast cancer.pdf (1.455Mb)
Date
2020
Author
Unver, Nese and Yoyen Ermis, Digdem and Weber, Bahar Zehra and Esendagli, Gunes
xmlui.mirage2.itemSummaryView.MetaData
Show full item record
Abstract
CD40 is an important tumor necrosis factor receptor (TNFR) family protein for the development of antitumor response against cancer cells, apart from its role in the regulation of the immune system as a costimulatory molecule. It is broadly expressed on the surface of immune cells and in diverse cancer types, including breast cancer. Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype. We detected CD40 gene expression along with its 3 different splice variants (variants 1-3), predominantly in the triple-negative subgroup of breast cancer cell lines. The results of the overall survival analysis showed that high CD40 gene expression, particularly in the triple-negative subgroup of breast cancer patients, is associated with better survival. In addition to the transcriptional levels of CD40 splice variants, investigation of protein levels of these variants will allow the categorization of breast cancer cells and reveal their potential as an immunotherapeutic target.
URI
http://hdl.handle.net/20.500.12591/214
xmlui.mirage2.itemSummaryView.Collections
  • PubMed İndeksli Yayınlar
  • Scopus İndeksli Yayınlar
  • TR-DİZİN İndeksli Yayınlar
  • Web of Science İndeksli Yayınlar
  • Web of Science İndeksli Yayınlar
  • WOS İndeksli Yayınlar Koleksiyonu





Creative Commons License
DSpace@LokmanHekim by Lokman Hekim University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV
 

 



About HUAES
Open Access PolicyOpen Access InstructionGuidesSubcriptionsContact
sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV