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Regioselective N–alkylation of 2– (3,4–dimethoxyphenyl)imidazo[4,5–b] and [4,5–c]pyridine oxide derivatives: Synthesis and structure elucidation by NMR

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Date
2019
Author
Göker, H. and Özden, S.
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Abstract
Imidazopyridines can exist in several tautomeric forms such as benzimidazole or purine condensed systems. Regioselectivities were determined for N-alkylations of 2-(3,4-dimethoxyphenyl)- imidazopyridines and their 4 and 5-oxides (2–4, 13, 14) with n-butyl and 4-fluorobenzyl bromides under basic conditions (K2CO3 in DMF). It was observed that N-4 (5–8) and N-5 (15–17) regioisomers were mainly formed. Compounds 7 (N4) and 7a (N1) were separated from the mixtures of regioisomers in a 50: 1 ratio. Their structural assignments were made with the use of two-dimensional 1H-1H NOE (nuclear overhauser effect spectroscopy [NOESY]) enhancements between the N-CH2 and protons on the C-4, 5, 6, and 7 positions of the pyridine moiety. To verify the NOESY data, synthesis of compounds 7a and 7b was achieved by the selective method. Complementary structural information was provided by 2D-HMBC spectra of the compounds. © 2019 Elsevier B.V.
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http://hdl.handle.net/20.500.12591/328
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