The Effects of Riluzole on Cisplatin-induced Ototoxicity
Date
2019Author
Bezgin, Selin Ustun
Uygur, Kadir Kemal
Gokdogan, Cagil
Elmas, Cigdem
Goktas, Guleser
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Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is
known as a neuroprotective, antioxidant, antiapoptotic agent. It may
have beneficial effects on neuronal cell death due to cisplatin-induced
ototoxicity. Objective To evaluate the effect of riluzole on
cisplatin-induced ototoxicity in guinea pigs. Methods Twenty-four guinea
pigs, studied in three groups, underwent auditory brainstem response
evaluation using click and 8 kHz tone burst stimuli. Subsequently, 5
mg/kg of cisplatin were administered to all animals for 3 days
intraperitoneally (i.p.) to induce ototoxicity. Half an hour prior to
cisplatin, groups 1, 2 and 3 received 2 ml of saline i.p., 6 mg/kg of
riluzole hydrochloride i.p., and 8 mg/kg of riluzole hydrochloride i.p.,
respectively, for 3 days. The auditory brainstem responses were repeated
24 hours after the last drug administration. The cochleae were analyzed
by transmission electron microscopy (TEM). Results After drug
administiration, for 8,000 Hz stimulus, group 1 had significantly higher
threshold shifts when compared with groups 2 ( p < 0.05) and 3 ( p <
0.05), and there was no significant difference in threshold shifts
between groups 2 and 3 ( p > 0.05). Transmission electron microscopy
findings demonstrated the protective effect of riluzole on the hair
cells and the stria vascularis, especially in the group treated with 8
mg/kg of riluzole hydrochloride. Conclusion We can say that riluzole may
have a protective effect on cisplatin- induced ototoxicity. However,
additional studies are needed to confirm these results and the
mechanisms of action of riluzole.
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