Urinary bisphenol-A levels in children with type 1 diabetes mellitus
Date
2018Author
Ince, Tolga
Balci, Aylin
Yalcin, Siddika Songul
Ozkemahli, Gizem
Erkekoglu, Pinar
Kocer-Gumusel, Belma
Yurdakok, Kadriye
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Background: Bisphenol-A (BPA) is one of the most abundantly produced
chemicals globally. Concerns have been raised about BPA's possible role
in the pathogenesis of type 1 diabetes mellitus (T1DM). The main aim of
the current study was to evaluate the possible association between BPA
exposure and T1DM. The second aim was to investigate children's possible
BPA exposure routes in Turkey.
Methods: A total of 100 children aged between 5 and 18 years including
50 children with T1DM and 50 healthy children were included. Urinary BPA
levels of all children were measured using high-performance liquid
chromatography. Mothers of children enrolled in the study were also
requested to complete a survey that included questions on the
sociodemographic characteristics, medical history and possible BPA
exposure routes of their children.
Results: In the T1DM group, urinary BPA levels were slightly higher
compared to the control group, but this difference was not significant
(p = 0.510). however, there was an inverse relationship between current
urinary BPA levels and birth weight. It was found that the use of
plastic kettles and the consumption of dairy products in plastic boxes
significantly increased the urinary BPA concentrations in all subjects.
Conclusions: Although there was no significant association between
urinary BPA levels and T1DM, we found an inverse relationship between
current urinary BPA levels and birth weight. This finding might be
important for prenatal exposure, and further prospective research must
be conducted. Also, the use of plastic kettles, which has not been
mentioned much in the literature before, was found to be an important
exposure route for BPA.
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