Assessment-of-oxidant-antioxidant status-alteratiohs with tumor biomarkers and reproductive system hormones in uterine MYOMAS
Date
2018Author
Caglayan, Aydan
Katlan, Doruk Cevdi
Tuncer, Zafer Selcuk
Yuce, Kunter
Sayal, Hasan Berkan
Kocer-Gumusel, Belma
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Objectives: Uterine myomas (UM) are responsible for significant
morbidity and have adverse effects on quality of life in women. Reactive
oxygen species (ROS) and antioxidant enzymes (AOE), as well as sex
steroids play important roles in the reproductive physiology processes.
Thus, we aimed to investigate the role of oxidant-antioxidant status in
UM by measuring the AOE activities and lipid peroxidation (LPO) levels.
This is the first study assessing these parameters together in UM based
on also menopausal status and evaluating possible correlations between
AOE activities, LPO markers, tumor biomarkers, female reproductive
system hormone levels, comprehensively.
Study Design: The study group consisted of patients who have undergone
surgical resection with confirmed pathology of uterine myoma (UM, n =
25) and divided into subgroups; premenopausal (UMpre) and postmenopausal
(UMpost). Erythrocyte copper-zinc superoxide dismutase (Cu,Zn-SOD),
catalase (CAT), glutathione peroxidase (GPx1) activities were measured
along with plasma malondialdehyde (MDA) and urinary 8-epi-prostaglandin
F2 alpha (8-epi-PGF2 alpha) levels in patients with UM. The obtained
data were compared to the data of healthy individuals (C, n = 25) and
its subgroups; premenopausal (C-pre) and postmenopausal (cost).
Results: All AOE activities were higher (similar to 40\% for Cu,Zn-SOD,
p = 0.003; similar to 55\% for CAT, p = 0.001; similar to 15\% for GPx1,
p = 0.169) and the LPO levels were lower (similar to 60\% for MDA, p =
0.011 and similar to 45\% for 8-epi-PGF2 alpha, p = 0.055) in patients
with UM vs control. Approximately similar alterations were observed in
UMpre vs C-pre and in UMpost vs C-post. A significant negative
correlation between erythrocyte Cu,Zn-SOD activity and plasma MDA levels
(r = -0.431, p = 0.005) was reported.
Conclusion: Decreased LPO levels might be the consequence of compensator
high antioxidant enzyme activities against mild oxidative stress in the
circulation of patients with UM. The marked negative correlation between
erythrocyte Cu,Zn-SOD activity and plasma MDA levels also supported this
finding. (C) 2018 Elsevier B.V. All rights reserved.
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