• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • ECZACILIK FAKÜLTESİ
  • Makale
  • Web of Science İndeksli Yayınlar
  • View Item
  •   DSpace Home
  • ECZACILIK FAKÜLTESİ
  • Makale
  • Web of Science İndeksli Yayınlar
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Assessment-of-oxidant-antioxidant status-alteratiohs with tumor biomarkers and reproductive system hormones in uterine MYOMAS

Thumbnail
Date
2018
Author
Caglayan, Aydan
Katlan, Doruk Cevdi
Tuncer, Zafer Selcuk
Yuce, Kunter
Sayal, Hasan Berkan
Kocer-Gumusel, Belma
xmlui.mirage2.itemSummaryView.MetaData
Show full item record
Abstract
Objectives: Uterine myomas (UM) are responsible for significant morbidity and have adverse effects on quality of life in women. Reactive oxygen species (ROS) and antioxidant enzymes (AOE), as well as sex steroids play important roles in the reproductive physiology processes. Thus, we aimed to investigate the role of oxidant-antioxidant status in UM by measuring the AOE activities and lipid peroxidation (LPO) levels. This is the first study assessing these parameters together in UM based on also menopausal status and evaluating possible correlations between AOE activities, LPO markers, tumor biomarkers, female reproductive system hormone levels, comprehensively. Study Design: The study group consisted of patients who have undergone surgical resection with confirmed pathology of uterine myoma (UM, n = 25) and divided into subgroups; premenopausal (UMpre) and postmenopausal (UMpost). Erythrocyte copper-zinc superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GPx1) activities were measured along with plasma malondialdehyde (MDA) and urinary 8-epi-prostaglandin F2 alpha (8-epi-PGF2 alpha) levels in patients with UM. The obtained data were compared to the data of healthy individuals (C, n = 25) and its subgroups; premenopausal (C-pre) and postmenopausal (cost). Results: All AOE activities were higher (similar to 40\% for Cu,Zn-SOD, p = 0.003; similar to 55\% for CAT, p = 0.001; similar to 15\% for GPx1, p = 0.169) and the LPO levels were lower (similar to 60\% for MDA, p = 0.011 and similar to 45\% for 8-epi-PGF2 alpha, p = 0.055) in patients with UM vs control. Approximately similar alterations were observed in UMpre vs C-pre and in UMpost vs C-post. A significant negative correlation between erythrocyte Cu,Zn-SOD activity and plasma MDA levels (r = -0.431, p = 0.005) was reported. Conclusion: Decreased LPO levels might be the consequence of compensator high antioxidant enzyme activities against mild oxidative stress in the circulation of patients with UM. The marked negative correlation between erythrocyte Cu,Zn-SOD activity and plasma MDA levels also supported this finding. (C) 2018 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/20.500.12591/175
xmlui.mirage2.itemSummaryView.Collections
  • Web of Science İndeksli Yayınlar





Creative Commons License
DSpace@LokmanHekim by Lokman Hekim University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV
 

 



About HUAES
Open Access PolicyOpen Access InstructionGuidesSubcriptionsContact
sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV