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dc.contributor.authorSunman, Birce and Yurdakok, Kadriye and Kocer-Gumusel, Belma and Ozyuncu, Ozgur and Akbiyik, Filiz and Balci, Aylin and Ozkemahli, Gizem and Erkekoglu, Pinar and Yurdakok, Murat
dc.date.accessioned2020-10-14T08:43:22Z
dc.date.available2020-10-14T08:43:22Z
dc.date.issued2019
dc.identifier10.1016/j.reprotox.2019.05.065
dc.identifier.issn0890-6238
dc.identifier.urihttp://hdl.handle.net/20.500.12591/169
dc.description.abstractBisphenol A (BPA) and phthalates can adversely affect the fetal development. However, observational studies on the effects of these chemicals on fetal male reproductive system are still limited. A hundred of umbilical cord blood samples were analyzed for the levels of BPA, di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and sex hormones. After birth, male newborns underwent physical examination that included measurements of anogenital distance, stretched penile length (SPL), and penile width. BPA, DEHP and MEHP levels were detectable in approximate to 99\% of cord blood samples. In covariate-adjusted models, cord blood BPA levels were inversely associated with SPL of newborns and positively associated with cord blood estradiol levels. In addition, there was a significant inverse relationship between cord blood DEHP levels and anogenital distance index of newborn males. Our results suggest that in utero BPA and DEHP exposure exerted adverse effects on fetal male reproductive development and cord blood estradiol levels.
dc.sourceREPRODUCTIVE TOXICOLOGY
dc.titlePrenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels


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