Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto's thyroiditis
Date
2019Author
Sur, Unzile and Erkekoglu, Pinar and Bulus, Ayse Derya and Andiran,
Nesibe and Kocer-Gumusel, Belma
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In this study, we aimed to investigate whether bisphenol A (BPA) and
di-(2-ethylhexyl) phthalate (DEHP) exposure have any association with
Hashimoto's thyroiditis (HT) and its biomarkers and to determine whether
oxidative stress biomarkers and trace element levels showed any
alterations in children with HT. We found that superoxide dismutase and
glutathione peroxidase activities are lower in HT group from control
(24\% and 46\%, respectively, p < 0.05). Zinc levels were significantly
lower in HT group vs. control. In addition, the levels of
mono-(2-ethylhexyl) phthalate (MEHP) which is the primary metabolite for
DEHP, were markedly higher in HT group compared to control (p < 0.05). A
negative correlation was observed between urinary BPA levels and fT4. In
children with HT, oxidant/antioxidant balance is changed and these
differences may be related by EDC exposure, the importance of which
should be elucidated with further studies.
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