The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats
Date
2020Author
Yilmaz-Oral, Didem and Onder, Alev and Gur, Serap and
Carbonell-Barrachina, Angel A. and Kaya-Sezginer, Ecem and Oztekin,
Cetin Volkan and Zor, Murat
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Diabetic men are at a higher risk of erectile dysfunction (ED). A
tropical plant, clove (Syn. Eugenia caryophyllata, Caryophyllus
aromaticus L., Syzygium aromaticum (L.) Merr. \& L.M. Perry) from the
Myrtaceae family has displayed aphrodisiac activity. The present
research aimed to investigate the impacts of clove essential oil (CEO)
and the ingredient of CEO, eugenol (E) on ED in diabetic rats. We
divided Sprague-Dawley rats into control and diabetic groups. Erectile
function was evaluated before and after CEO and E intracavernosal
injection. CEO- and E-induced relaxation responses were investigated in
isolated corpus cavernosum (CC) using various inhibitors. The
intracavernous administration of CEO and E restored erectile responses
in diabetic rats. CEO and E induced remarkable relaxation in all groups.
CEO- and E-induced relaxation responses were partially inhibited after
pre-contraction with KCl. Tetraethylammonium and glibenclamide inhibited
the relaxation response to CEO. Glibenclamide inhibited maximum
relaxation to E. The inhibitors of nitric oxide synthase (NOS), soluble
guanylyl cyclase and nifedipine did not change CEO- and E-induced
relaxation responses. The current results suggest that CEO and the major
compound of the essential oil, E improved diabetes-induced ED in rats,
and CEO caused CC relaxation via K+ channels independently NO signalling
pathway.
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