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dc.contributor.authorBalci, Aylin
dc.contributor.authorOzkemahli, Gizem
dc.contributor.authorErkekoglu, Pinar
dc.contributor.authorZeybek, Dilara
dc.contributor.authorYersal, Nilgun
dc.contributor.authorKocer-Gumusel, Belma
dc.date.accessioned2020-10-14T08:43:21Z
dc.date.available2020-10-14T08:43:21Z
dc.identifier10.1080/09603123.2020.1805416
dc.identifier.issn0960-3123
dc.identifier.urihttp://hdl.handle.net/20.500.12591/156
dc.description.abstractBisphenol A (BPA) and phthalates are abundantly used endocrine disrupting chemicals (EDCs). The aim of this study was to evaluate the effects of single and combined exposures to BPA and/or di(2-ethylhexyl) phthalate (DEHP) in prenatal and lactational period on rat male reproductive system in later stages of life. Pregnant Sprague-Dawley rats were divided randomly to four groups (n= 3/group): Control (corn oil); DEHP (30 mg/kg/day); BPA (50 mg/kg/day); and BPA+ DEHP (30 mg/kg/day DEHP and 50 mg/kg/day BPA). Groups exposed to EDCs through 6-21 gestational days and lactation period by intragastric lavage. Male offspring (n= 6/group) from each mother were fed till adulthood and were then euthanized. Later, reproductive hormones, sperm parameters, and oxidative stress parameters were determined. In conclusion, we can suggest that prenatal and lactational exposure to BPA and DEHP may cause adverse effects in male reproductive system in later stages of life especially after combined exposure.
dc.sourceINTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
dc.titleEffects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system


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