Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system
Author
Balci, Aylin
Ozkemahli, Gizem
Erkekoglu, Pinar
Zeybek, Dilara
Yersal, Nilgun
Kocer-Gumusel, Belma
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Bisphenol A (BPA) and phthalates are abundantly used endocrine
disrupting chemicals (EDCs). The aim of this study was to evaluate the
effects of single and combined exposures to BPA and/or di(2-ethylhexyl)
phthalate (DEHP) in prenatal and lactational period on rat male
reproductive system in later stages of life. Pregnant Sprague-Dawley
rats were divided randomly to four groups (n= 3/group): Control (corn
oil); DEHP (30 mg/kg/day); BPA (50 mg/kg/day); and BPA+ DEHP (30
mg/kg/day DEHP and 50 mg/kg/day BPA). Groups exposed to EDCs through
6-21 gestational days and lactation period by intragastric lavage. Male
offspring (n= 6/group) from each mother were fed till adulthood and were
then euthanized. Later, reproductive hormones, sperm parameters, and
oxidative stress parameters were determined. In conclusion, we can
suggest that prenatal and lactational exposure to BPA and DEHP may cause
adverse effects in male reproductive system in later stages of life
especially after combined exposure.
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