Now showing items 1-10 of 13
The Effects of Riluzole on Cisplatin-induced Ototoxicity.
(Tıp Fakültesi, 2019-03-01)
Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. To evaluate ...
The impact of At1r inhibition via losartan on the anti-leukaemic effects of doxorubicin in acute myeloid leukaemia.
(Tıp Fakültesi, 2019-04-20)
Introduction: Bone marrow renin-angiotensin system(RAS) modulates acute myeloid leukaemia(AML).The aim of this study is to clarify the relationships between RAS and AML, and to show the effect of losartan and doxorubicin ...
Is leptin receptor expression triggered in the case of embryo transfer to endometrium coculture?
(Tıp Fakültesi, 2019-08-08)
Background/aim: A synchronized dialogue between maternal and embryonic tissues is required for successful implantation. Low uterine receptivity is responsible for two-thirds of implantation failures and leptin is effective ...
INVESTIGATING EFFECTS OF GRAPE SEED EXTRACT ON NEUROPATHIC PAIN IN THE STREPTOZOTOCIN-INDUCED DIABETIC MICE
Diabetes mellitus is a complicated and serious health problem involving peripheral neuropathy. This situation causes to loss of senses, tingle and pain. Diabetic peripheral neuropathy (DPN) affects 236 million people around ...
Neuroprotective role of delta opioid receptors in hypoxic preconditioning
Background/aim: The purpose of the present study was to explore the neuroprotective role of delta opioid receptors (DOR) in the rat cortex in hypoxic preconditioning. Materials and methods: Rats were randomly divided ...
Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS.
(Tıp Fakültesi, 2019-08-12)
Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms ...