Now showing items 1-6 of 6
Bimodal Effects of P2Y Antagonism on Matrix Metalloproteinase-Associated Contractile Dysfunction in İnsulin-Resistant Mammalian Heart.
(Tıp Fakültesi, 2021-07-16)
The matrix metalloproteinases (MMPs) contribute to matrix remodeling in diabetes via tissue degradation; however, their contributions can be different depending on the pathology. For instance, MMPs are elevated in acute ...
Glucagon-like peptide-1 receptor agonist treatment of high carbohydrate intake-induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and intracellular Ca abnormalities and mitochondrial dysfunction.
(Tıp Fakültesi, 2021-09-14)
The pleiotropic effects of glucagon-like peptide-1 receptor (GLP-1R) agonists on the heart have been recognised in obese or diabetic patients. However, little is known regarding the molecular mechanisms of these agonists ...
Insulin acts as an atypical KCNQ1/KCNE1-current activator and reverses long QT in insulin-resistant aged rats by accelerating the ventricular action potential repolarization through affecting the β -adrenergic receptor signaling pathway.
(Tıp Fakültesi, 2021-10-10)
Insufficient-heart function is associated with myocardial insulin resistance in the elderly, particularly associated with long-QT, in a dependency on dysfunctional KCNQ1/KCNE1-channels. So, we aimed to examine the contribution ...
The role of labile Zn and Zn-transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes.
(Tıp Fakültesi, 2021-02-01)
An important energy supplier of cardiomyocytes is mitochondria, similar to other mammalian cells. Studies have demonstrated that any defect in the normal processes controlled by mitochondria can lead to abnormal ROS ...
Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity.
(Tıp Fakültesi, 2021-04-01)
Consumption of illicit pharmaceutical products containing sibutramine has been reported to cause cardiovascular toxicity problems. This study aimed to demonstrate the toxicity profile of sibutramine, and thereby provide ...
Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart.
(Tıp Fakültesi, 2021-03-11)
Excessive mitochondrial ROS production has been causally linked to the pathophysiology of aging in the heart and other organs, and plays a deleterious role in several age-related cardiac pathologies, including myocardial ...