Browsing by Author "Olgar, Yusuf"
Now showing items 1-4 of 4
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Bimodal Effects of P2Y Antagonism on Matrix Metalloproteinase-Associated Contractile Dysfunction in İnsulin-Resistant Mammalian Heart.
Olgar, Yusuf; Tuncay, Erkan; Billur, Deniz; Turan, Belma (Tıp Fakültesi, 2021-07-16)The matrix metalloproteinases (MMPs) contribute to matrix remodeling in diabetes via tissue degradation; however, their contributions can be different depending on the pathology. For instance, MMPs are elevated in acute ... -
Insulin acts as an atypical KCNQ1/KCNE1-current activator and reverses long QT in insulin-resistant aged rats by accelerating the ventricular action potential repolarization through affecting the β -adrenergic receptor signaling pathway.
Olgar, Yusuf; Durak, Aysegul; Bitirim, Ceylan V; Tuncay, Erkan; Turan, Belma (Tıp Fakültesi, 2021-10-10)Insufficient-heart function is associated with myocardial insulin resistance in the elderly, particularly associated with long-QT, in a dependency on dysfunctional KCNQ1/KCNE1-channels. So, we aimed to examine the contribution ... -
Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity.
Alyu, Feyza; Olgar, Yusuf; Degirmenci, Sinan; Turan, Belma; Ozturk, Yusuf (Tıp Fakültesi, 2021-04-01)Consumption of illicit pharmaceutical products containing sibutramine has been reported to cause cardiovascular toxicity problems. This study aimed to demonstrate the toxicity profile of sibutramine, and thereby provide ... -
Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum-mitochondria miscommunication.
Olgar, Yusuf; Durak, Aysegul; Degirmenci, Sinan; Tuncay, Erkan; Billur, Deniz; Ozdemir, Semir; Turan, Belma (Tıp Fakültesi, 2021-06-10)Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated cardiovascular dysfunction and increased platelet P2Y12 receptor ...
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